DESCRIPTION:
One compartment TMDD model assuming doses injected directly into central compartment


[LONGITUDINAL]
input = {kel, kep, kon, kout, koff, Vc, R0}

PK:
; Dosemg: Dose injected into central compartment (mg/kg)
; MWlig=150000; molecular weight of ligand (Da) 
; (Dosemg*1e-3/MWlig)*1e9 ; Dose conversion (nmol/kg)

depot(target=L, p=100/15/Vc)  ; L is a concentration (nM)

EQUATION:
kin   = kout*R0 ; Synthesis of receptor (nM/day)

;Initial Conditions
R_0 = R0
P_0 = 0

;Ordinary Differential Equations
ddt_L = -kel*L-kon*L*R+koff*P 
ddt_R = kin-kout*R-kon*L*R+koff*P
ddt_P = kon*L*R-koff*P-kep*P

;Ltot and Rtot
Lt = L+P; Total concentration of ligand (nM)
Rt = R+P; Total concentration of receptor (nM)
